Endocrine Abstracts

Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in variety of biological processes including energy metabolism, reproduction and modulation of the immune response. So far structural elements affecting leptin binding to its receptor remain unknown. We employed random mutagenesis of leptin, followed by selection of high-affinity mutants by yeast-surface display and discovered that replacing residue D23 with a non-negatively charged amino a...

A 51 year old woman was referred for investigation of goitre. The patient described weight loss, sweating and hot flushes for 3 years. A bilateral salpingo-oophorectomy had been performed 14 years prior to presentation but the patient had been off HRT for 12 years.On examination the patient was thin, nervous and sweaty with a sinus tachycardia and a smooth goitre, but no signs of thyroid eye disease.Thyroid hormone levels were elev...